A Longitudinal, Multi-Project Study of Bug Tracking Productivity and Learning in Open Source Software Development

The dynamics of Open Source Software development haverecently received a lot of attention from an organizationallearning perspective. Following a network theoretic approach,we study the temporal development of communication networkstructure and productivity in order to detect associationsamong these constructs. Thereby, we identify a researchgap in that related work either focuses on too fewprojects or utilizes insucient numbers of analyzed timeframes.Our study is both multi-project and longitudinal inorder to detect holistic inuencing factors of successful OpenSource Software development. First, we nd that learningeects are present since productivity increases over time.Next, we observe that growth in team size impedes productivitywhereas the continuous concentration on centralnodes coincides with increasing productivity. Against ourexpectation, we also nd that increasing centralization doesnot yield decreasing network density, possibly due to OpenSource Software developers deliberately avoiding the dependenceon bottleneck nodes

Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo: a comparative study in rabbits

<p>Abstract</p> <p>Background</p> <p>Recent studies have shown the potential suitability of magnesium alloys as biodegradable implants. The aim of the present study was to compare the soft tissue biocompatibility of MgCa0.8 and commonly used surgical steel <it>in vivo</it>.</p> <p>Methods</p> <p>A biodegradable magnesium calcium alloy (MgCa0.8) and surgical steel (S316L), as a control, were investigated. Screws of identical geometrical conformation were implanted into the tibiae of 40 rabbits for a postoperative follow up of two, four, six and eight weeks. The tibialis cranialis muscle was in direct vicinity of the screw head and thus embedded in paraffin and histologically and immunohistochemically assessed. Haematoxylin and eosin staining was performed to identify macrophages, giant cells and heterophil granulocytes as well as the extent of tissue fibrosis and necrosis. Mouse anti-CD79α and rat anti-CD3 monoclonal primary antibodies were used for B- and T-lymphocyte detection. Evaluation of all sections was performed by applying a semi-quantitative score.</p> <p>Results</p> <p>Clinically, both implant materials were tolerated well. Histology revealed that a layer of fibrous tissue had formed between implant and overlying muscle in MgCa0.8 and S316L, which was demarcated by a layer of synoviocyte-like cells at its interface to the implant. In MgCa0.8 implants cavities were detected within the fibrous tissue, which were surrounded by the same kind of cell type. The thickness of the fibrous layer and the amount of tissue necrosis and cellular infiltrations gradually decreased in S316L. In contrast, a decrease could only be noted in the first weeks of implantation in MgCa0.8, whereas parameters were increasing again at the end of the observation period. B-lymphocytes were found more often in MgCa0.8 indicating humoral immunity and the presence of soluble antigens. Conversely, S316L displayed a higher quantity of T-lymphocytes.</p> <p>Conclusions</p> <p>Moderate inflammation was detected in both implant materials and resolved to a minimum during the first weeks indicating comparable biocompatibility for MgCa0.8 and S316L. Thus, the application of MgCa0.8 as biodegradable implant material seems conceivable. Since the inflammatory parameters were re-increasing at the end of the observation period in MgCa0.8 it is important to observe the development of inflammation over a longer time period in addition to the present study.</p

NimbleAI: towards neuromorphic sensing-processing 3D-integrated chips

The NimbleAI Horizon Europe project leverages key principles of energy-efficient visual sensing and processing in biological eyes and brains, and harnesses the latest advances in 33D stacked silicon integration, to create an integral sensing-processing neuromorphic architecture that efficiently and accurately runs computer vision algorithms in area-constrained endpoint chips. The rationale behind the NimbleAI architecture is: sense data only with high information value and discard data as soon as they are found not to be useful for the application (in a given context). The NimbleAI sensing-processing architecture is to be specialized after-deployment by tunning system-level trade-offs for each particular computer vision algorithm and deployment environment. The objectives of NimbleAI are: (1) 100x performance per mW gains compared to state-of-the-practice solutions (i.e., CPU/GPUs processing frame-based video); (2) 50x processing latency reduction compared to CPU/GPUs; (3) energy consumption in the order of tens of mWs; and (4) silicon area of approx. 50 mm 2 .NimbleAI has received funding from the EU’s Horizon Europe Research and Innovation programme (Grant Agreement 101070679), and by the UK Research and Innovation (UKRI) under the UK government’s Horizon Europe funding guarantee (Grant Agreement 10039070)Peer ReviewedArticle signat per 49 autors/es: Xabier Iturbe, IKERLAN, Basque Country (Spain); Nassim Abderrahmane, MENTA, France; Jaume Abella, Barcelona Supercomputing Center (BSC), Catalonia, Spain; Sergi Alcaide, Barcelona Supercomputing Center (BSC), Catalonia, Spain; Eric Beyne, IMEC, Belgium; Henri-Pierre Charles, CEA-LIST, University Grenoble Alpes, France; Christelle Charpin-Nicolle, CEALETI, Univ. Grenoble Alpes, France; Lars Chittka, Queen Mary University of London, UK; Angélica Dávila, IKERLAN, Basque Country (Spain); Arne Erdmann, Raytrix, Germany; Carles Estrada, IKERLAN, Basque Country (Spain); Ander Fernández, IKERLAN, Basque Country (Spain); Anna Fontanelli, Monozukuri (MZ Technologies), Italy; José Flich, Universitat Politecnica de Valencia, Spain; Gianluca Furano, ESA ESTEC, Netherlands; Alejandro Hernán Gloriani, Viewpointsystem, Austria; Erik Isusquiza, ULMA Medical Technologies, Basque Country (Spain); Radu Grosu, TU Wien, Austria; Carles Hernández, Universitat Politecnica de Valencia, Spain; Daniele Ielmini, Politecnico Milano, Italy; David Jackson, University of Manchester, UK; Maha Kooli, CEA-LIST, University Grenoble Alpes, France; Nicola Lepri, Politecnico Milano, Italy; Bernabé Linares-Barranco, CSIC, Spain; Jean-Loup Lachese, MENTA, France; Eric Laurent, MENTA, France; Menno Lindwer, GrAI Matter Labs (GML), Netherlands; Frank Linsenmaier, Viewpointsystem, Austria; Mikel Luján, University of Manchester, UK; Karel Masařík, CODASIP, Czech Republic; Nele Mentens, Universiteit Leiden, Netherlands; Orlando Moreira, GrAI Matter Labs (GML), Netherlands; Chinmay Nawghane, IMEC, Belgium; Luca Peres, University of Manchester, UK; Jean-Philippe Noel, CEA-LIST, University Grenoble Alpes, France; Arash Pourtaherian, GrAI Matter Labs (GML), Netherlands; Christoph Posch, PROPHESEE, France; Peter Priller, AVL List, Austria; Zdenek Prikryl, CODASIP, Czech Republic; Felix Resch, TU Wien, Austria; Oliver Rhodes, University of Manchester, UK; Todor Stefanov, Universiteit Leiden, Netherlands; Moritz Storring, IMEC, Belgium; Michele Taliercio, Monozukuri (MZ Technologies), Italy; Rafael Tornero, Universitat Politecnica de Valencia, Spain; Marcel van de Burgwal, IMEC, Belgium; Geert van der Plas, IMEC, Belgium; Elisa Vianello, CEALETI, Univ. Grenoble Alpes, France; Pavel Zaykov, CODASIP, Czech RepublicPostprint (author's final draft

The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

PMCID: PMC3410907This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression

We aimed to assess whether pri-miRNA SNPs (miSNPs) could influence monocyte gene expression, either through marginal association or by interacting with polymorphisms located in 3'UTR regions (3utrSNPs). We then conducted a genome-wide search for marginal miSNPs effects and pairwise miSNPs × 3utrSNPs interactions in a sample of 1,467 individuals for which genome-wide monocyte expression and genotype data were available. Statistical associations that survived multiple testing correction were tested for replication in an independent sample of 758 individuals with both monocyte gene expression and genotype data. In both studies, the hsa-mir-1279 rs1463335 was found to modulate in cis the expression of LYZ and in trans the expression of CNTN6, CTRC, COPZ2, KRT9, LRRFIP1, NOD1, PCDHA6, ST5 and TRAF3IP2 genes, supporting the role of hsa-mir-1279 as a regulator of several genes in monocytes. In addition, we identified two robust miSNPs × 3utrSNPs interactions, one involving HLA-DPB1 rs1042448 and hsa-mir-219-1 rs107822, the second the H1F0 rs1894644 and hsa-mir-659 rs5750504, modulating the expression of the associated genes. As some of the aforementioned genes have previously been reported to reside at disease-associated loci, our findings provide novel arguments supporting the hypothesis that the genetic variability of miRNAs could also contribute to the susceptibility to human diseases

EFTfitter: A tool for interpreting measurements in the context of effective field theories

Over the past years, the interpretation of measurements in the context of effective field theories has attracted much attention in the field of particle physics. We present a tool for interpreting sets of measurements in such models using a Bayesian ansatz by calculating the posterior probabilities of the corresponding free parameters numerically. An example is given, in which top-quark measurements are used to constrain anomalous couplings at the Wtb-vertex.The authors would like to thank Fabian Bach, Kathrin Becker, Dominic Hirschbühl and Mikolaj Misiak for their help and for the fruitful discussions. In particular, the authors would like to thank Fabian Bach for providing the code for the single-top cross sections. N.C. acknowledges the support of FCT-Portugal through the contract IF/00050/2013/CP1172/CT00

RANTES/CCL5 and risk for coronary events:Results from the MONICA/KORA Augsburg case-cohort, Athero-express and CARDIoGRAM studies

Background: The chemokine RANTES (regulated on activation, normal T-cell expressed and secreted)/CCL5 is involved in the pathogenesis of cardiovascular disease in mice, whereas less is known in humans. We hypothesised that its relevance for atherosclerosis should be reflected by associations between CCL5 gene variants, RANTES serum concentrations and protein levels in atherosclerotic plaques and risk for coronary events. Methods and Findings: We conducted a case-cohort study within the population-based MONICA/KORA Augsburg studies. Baseline RANTES serum levels were measured in 363 individuals with incident coronary events and 1,908 non-cases (mean follow-up: 10.2±4.8 years). Cox proportional hazard models adjusting for age, sex, body mass index, metabolic factors and lifestyle factors revealed no significant association between RANTES and incident coronary events (HR [95% CI] for increasing RANTES tertiles 1.0, 1.03 [0.75-1.42] and 1.11 [0.81-1.54]). None of six CCL5 single nucleotide polymorphisms and no common haplotype showed significant associations with coronary events. Also in the CARDIoGRAM study (&gt;22,000 cases, &gt;60,000 controls), none of these CCL5 SNPs was significantly associated with coronary artery disease. In the prospective Athero-Express biobank study, RANTES plaque levels were measured in 606 atherosclerotic lesions from patients who underwent carotid endarterectomy. RANTES content in atherosclerotic plaques was positively associated with macrophage infiltration and inversely associated with plaque calcification. However, there was no significant association between RANTES content in plaques and risk for coronary events (mean follow-up 2.8±0.8 years). Conclusions: High RANTES plaque levels were associated with an unstable plaque phenotype. However, the absence of associations between (i) RANTES serum levels, (ii) CCL5 genotypes and (iii) RANTES content in carotid plaques and either coronary artery disease or incident coronary events in our cohorts suggests that RANTES may not be a novel coronary risk biomarker. However, the potential relevance of RANTES levels in platelet-poor plasma needs to be investigated in further studies.</p